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STRUBE CONSULT

Statistical support, bioinformatics and scientific consulting

Adult Students
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ABOUT

I offer consultancy and support in all areas of the natural sciences, in particular within biology. Although my own research is focused on the microbiome, my expertise extends to all area of biology and I have successfully  worked with medical doctors, veterinarians and engineers on everything from animal genetics to biotechnology. I have a PhD from DTU and currently work as an Associate Professor at DTU BioEngineering.

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Eventually, this might be you:

"I am confident in the analysis, I understand it and I can write it in my paper."

STATISTICAL SUPPORT

You finally got that revolutionary data from your experiment or cohort, and you might even have a good idea on how to analyse it. Then you get stuck. You have to much data. You might even get a journal rejection due poor statistics. You try asking a colleague for help, but they might as well speak a different language. 

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This is where I come in. As both a trained a biologist and a good listener, I will understand the biology of your data as the very first thing. Next, I will use my experience from 60+ published papers to understand your scientific questions. Lastly, and only then, will I use my skills in data science to solve those questions.

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Often, scientists feel uncomfortable with statistical tests because they are unsure if they can explain the results confidently. This is key, whether it be at a conference or to a PI. Here, my role is to provide both the confidence and the proper language for such an explanation. 

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BIOINFORMATICS

You designed your revolutionary study, and decided to include analysis of the metagenome or metatranscriptome or metaproteome or metataxonome. You might even have had a good idea about how to analyze it. Then you got stuck on how to do the bioinformatics. Or you where overwhelmed at the sheer size of the data: 10,000 ASVs? 100,000 genes?

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This is where I come in. Apart from my experience in pure bioinformatics (including publishing my own software), I have extensive expertise, 60+ papers, in using multivariate statistics to make sense of such datasets, including their integration.

 

Often, most scientists feel alienated from their original data - or even lost - when their data is subjected to advanced analysis. Here, my role is to ensure a full understanding of the analytical concepts as well as the biological conclusions. 

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CONTACT ME

Contact me through the system below and we can discuss how to best handle your challenges. (english or danish!)

mikael.lenz.strube@gmail.com

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ACADEMIC PUBLICATIONS

  • Strube ML, Hansen JE, Rasmussen S, Pedersen K (2018) A detailed investigation of the porcine skin and nose microbiome using universal and Staphylococcus specific primers. Sci Rep 8:12751. doi: 10.1038/s41598-018-30689-y

  • Bønløkke S, Blaakær J, Steiniche T, Høgdall E, Jensen SG, Hammer A, Balslev E, Strube ML, Helle K, Lenz S (2018) Evidence of No Association Between Human Papillomavirus and Breast Cancer. Front Oncol 8:1–8. doi: 10.3389/fonc.2018.00209

  • Moreira TF, Filho EJF; Carvalho AU; Strube ML, Nielsen MW, Klitgaard K, Jensen TK (2018) Pathogens related to digital dermatitis in dairy cattle in all year round grazing system in Brazil. PLoS ONE 13(3): e0193870. https://doi.org/ 10.1371/journal.pone.0193870

  • Lenz K, Jensen K, Tanggaard K, Vazin M, Bendtsen TF, Chan V, Strube ML, Krogsgaard MR, Børglum J (2018) Comparing low volume saphenous-obturator block with placebo and femoral-obturator block for anterior cruciate ligament reconstruction: a randomized controlled trial. Minerva Anestesiologica. 84, 2:168-177. doi: http://dx.doi.org/10.23736/S0375-9393.17.11718-9

  • Sørensen MR, Ilsøe M, Strube ML, Bishop R, Erbs G, Hartmann SB, Jungersen G (2017) Sequence-based genotyping of expressed swine leukocyte antigen class I alleles by next-generation sequencing reveal novel swine leukocyte antigen class I haplotypes and alleles in Belgian, Danish, and Kenyan fattening pigs and Göttingen minipigs. Front Immunol 8:1–11. doi: 10.3389/fimmu.2017.00701

  • Klitgaard K, Strube ML, Isbrand A, Nielsen MW, Jensen TK (2017) Microbiota Analysis of an Environmental Slurry and Its Potential Role as a Reservoir of Bovine Digital Dermatitis Pathogens. Appl Environ Microbiol 83:1–8. doi: 10.1128/AEM.00244-17

  • Jers C, Strube ML, Cantor MD, Nielsen BKK, Sørensen OB, Boye M, Meyer AS (2017) Selection of Bacillus species for targeted in situ release of prebiotic galacto-rhamnogalacturonan from potato pulp in piglets. Appl Microbiol Biotechnol. doi: 10.1007/s00253-017-8176-x

  • Characterization of Campylobacter jejuni and Campylobacter coli Broiler Isolates by Whole-Genome Sequencing (2017). Cantero G, Correa-Fiz F, Ronco Troels, Strube ML, Cerdà-Cuéllar M,  Pedersen K. Foodborne Pathogens and Disease. Mar 2018.ahead of printhttp://doi.org/10.1089/fpd.2017.2325

  • Hedegaard CJ, Strube ML, Hansen MB, Lindved BK, Lihme A, Boye M, Heegaard PMH (2016) Natural Pig Plasma Immunoglobulins Have Anti-Bacterial Effects: Potential for Use as Feed Supplement for Treatment of Intestinal Infections in Pigs. PLoS One 11:e0147373. doi: 10.1371/journal.pone.0147373

  • Nielsen MW, Strube ML, Isbrand A, Al-Medrasi WDHM, Boye M, Jensen TK, Klitgaard K (2016) Potential bacterial core species associated with digital dermatitis in cattle herds identified by molecular profiling of interdigital skin samples. Vet Microbiol 186:139–149. doi: 10.1016/j.vetmic.2016.03.003

  • Opheim M, Lenz Strube M, Sterten H, Øverland M, Kjos NP (2016) Atlantic salmon ( Salmo salar ) protein hydrolysate in diets for weaning piglets ─ effect on growth performance, intestinal morphometry and microbiota composition. Arch Anim Nutr 70:44–56. doi: 10.1080/1745039X.2015.1117694

  • Strube ML, Jensen TK, Meyer AS, Boye M (2015) In situ prebiotics: Enzymatic release of galacto-rhamnogalacturonan from potato pulp in vivo in the gastrointestinal tract of the weaning piglet. AMB Express 5:66.

  • Strube ML, Ravn HC, Ingerslev H-C, Meyer AS, Boye M (2015b) In Situ Prebiotics for Weaning Piglets: In Vitro Production and Fermentation of Potato Galacto-Rhamnogalacturonan. Appl Environ Microbiol 81:1668–1678. doi: 10.1128/AEM.03582-14

  • Blair AR, Strube ML, Proietto J, Andrikopoulos S (2015) Improving Glucose Tolerance By Reducing Weight Gain In A Polygenic Obese Mouse Model – Use of a High Protein/Fibre Diet. Horm Metab Res 47:184–193.

  • Hermann-Bank ML, Skovgaard K, Stockmarr A, Strube ML, Larsen N, Kongsted H, Ingerslev H-C, Mølbak L, Boye M (2015) Characterization of the bacterial gut microbiota of piglets suffering from new neonatal porcine diarrhoea. BMC Vet Res 11:139. doi: 10.1186/s12917-015-0419-4

  • Ingerslev H-C, Strube ML, Jørgensen LVG, Dalsgaard I, Boye M, Madsen L (2014) Diet type dictates the gut microbiota and the immune response against Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 40:624–33. doi: 10.1016/j.fsi.2014.08.021

  • Ingerslev H-C, von Gersdorff Jørgensen L, Lenz Strube M, Larsen N, Dalsgaard I, Boye M, Madsen L (2014b) The development of the gut microbiota in rainbow trout (Oncorhynchus mykiss) is affected by first feeding and diet type. Aquaculture 424–425:24–34. doi: 10.1016/j.aquaculture.2013.12.032

  • Larsen DM, Nyffenegger C, Swiniarska MM, Thygesen A, Strube ML, Meyer AS, Mikkelsen JD (2014) Thermostability enhancement of an endo-1,4-β-galactanase from Talaromyces stipitatus by site-directed mutagenesis. Appl Microbiol Biotechnol. doi: 10.1007/s00253-014-6244-z

  • Strube ML, Meyer AS, Boye M (2013) Mini Review : Basic Physiology and Factors Influencing Exogenous Enzymes Activity in the Porcine Gastrointestinal Tract. Anim Nutr Feed Technol 13:441–459.

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